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Original Article
Apolipoprotein E Polymorphism and Plasma Lipid Levels in Obese Children
Myoung Hee Han, Sun Jun Kim
Clin Exp Pediatr. 2000;43(5):679-685.   Published online May 15, 2000
Purpose : The increased prevalence of dyslipoproteinemia in obese children probably contributes to the high risk of cardiovascular disease associated with being overweight. The genetic makeup is possible one of the factors that influence the impact of obesity on lipid metabolism. A relation between apolipoprotein E(Apo E) polymorphism and lipid metabolism has been convincingly demonstrated in large population. The purpose...
Comparative Reactivity of 2 TU and 5 TU PPD Skin Tests
Dae Sun Jo, Kyeong Mee Lee, Dae-Yeol Lee, Jung Soo Kim
Clin Exp Pediatr. 2000;43(5):638-643.   Published online May 15, 2000
Purpose : These days 5 TU purified protein derivative(PPD) is substituted with 2 TU PPD for the tuberculin skin test, a test essential in the diagnosis of tuberculosis in pediatric population. However, there had been no adequate criteria for the positivity of 2 TU PPD skin test. This study was performed to clarify the criteria of positive reactivity of 2...
Study of Autoantibodies Against Platelet GP IIb/IIIa and GP Ib/IX in Childhood Chronic Idiopathic Thrombocytopenic Purpura
Chanwook Woo, Junghwa Lee, Kwangchul Lee, Soonkyum Kim
Clin Exp Pediatr. 2000;43(3):395-401.   Published online March 15, 2000
Purpose : Chronic idiopathic thrombocytopenic purpura(CITP) is an autoimmune disease caused by autoantibodies reacting to certain antigens, and platelet glycoprotein(GP) IIb/IIIa and GP Ib/IX complexes are thought to be some of those antigens. However, the clinical significance of anti-GP autoantibodies in CITP patients is unknown. In this study, we investigated the clinical correlation between the presence of circulating autoantibodies against...
Apoptosis, P53, bax and Bcl-2 Protein Expressions in Neonatal rat Hippocampus by Kainic Acid-induced Seizure
Shin Weon Yun, Soo Ahn Chae, Eung sang Choi, Byoung Hoon Yoo
Clin Exp Pediatr. 2000;43(1):85-96.   Published online January 15, 2000
Purpose : Apoptosis is a process of active cell death which has been suggested to be part of hippocampal cell loss caused by kainic acid(KA). Immature rats showed higher susceptibility and mortality to KA but did not develop recurrent seizure, long term behavioral or neuropathologic changes. We investigated whether this was due to age-dependent resistance, and elucidated the molecular mechanics which mediate P53-induced apoptosis,...
Case Report
Follow up of a Case of Primary Intestinal Lymphangiectasia
Su Jeong Ha, Soo Jung Lee, Dae Kyun Koh
Clin Exp Pediatr. 1999;42(10):1452-1458.   Published online October 15, 1999
Primary intestinal lymphangiectasia is a rare congenital disorder characterized by diffuse or localized ectasia of the enteric lymphatics, often in association with lymphatic abnormalities elsewhere in the body. The pathogenesis of these abnormal lymphatic structures is uncertain. Ectatic lymphatics may be located in the mucosa, submucosa, or subserosa, leading to a loss of protein and lymphocytes into the gut or...
Original Article
Renal Problems in Wilson Disease
Il Soo Ha, Jun Ho Lee, Yeon Ho Choe, Hae Il Cheong, Sei Won Yang, Young Yull Koh, Jeong Kee Seo, Yong Choi
Clin Exp Pediatr. 1999;42(6):817-824.   Published online June 15, 1999
Purpose : Wilson disease is a hereditary metabolic disorder characterized by an accumulation of copper in tissues which sometimes results in renal problems. This study was performed to evaluate the prevalences of the renal problems in Wilson disease and related risk factors. Methods : In 31 patients with Wilson disease, we looked for renal problems by history taking, physical examination...
Intralipid Infusions Effect on Nutrophil Elastase Level in Newborns
Sue Jeen Min, Yong Woon Baek, Yong Woon Baek, Yong Woon Baek
Clin Exp Pediatr. 1999;42(5):666-671.   Published online May 15, 1999
Purpose : Parenteral nutrition is given to infants who tempararily cannot take oral feeding adequately. A lipid emulsion is added to the parenteral to supply essential fatty acids. In neonatal sepsis, elastase from azuropilic granules of the neutrophils is released and rapidly bound to α1- Proteinase Inhibitor(α1-PI). The lipid emulsion has been noted to markedly inhibit chemotaxis of neutrophils, so...
The Significance of Family History, Immunoglobulin E, Total Eosinophils and Eosinophil Cationic Protein as a Predictor of Allergic Diseases
Dong Su Park, Hyun Hee Kim, Joon Sung Lee
Clin Exp Pediatr. 1998;41(9):1273-1282.   Published online September 15, 1998
Purpose : Family history of allergy and cord blood immunoglobulin E concentration have been proven to be predictors of the development of allergic diseases in children. The purpose of this study is to evaluate whether maternal, cord and baby's blood total eosinophils or eosinophil cationic protein(ECP) in addition to the above two predictors could be a predictor of subsequent allergic...
C-Reactive Protein and Duration of Antibiotic Therapy in Neonatal Bacterial Infection
Jae Il Yoo, Jin Hwa Jeong, Jeong Ho Lee, Jong Dae Cho
Clin Exp Pediatr. 1998;41(7):901-908.   Published online July 15, 1998
Purpose : To determine whether C-reactive protein(CRP) can be used as a parameter to assess the safety of discontinuing antibiotic therapy and allows a shorter course of therapy in neonates treated for suspected bacterial infection. Methods : We have experienced 193 cases of suspected neonatal bacterial infection at Pusan Maryknoll Hospital. CRP levels were measured daily by immunonephelometry. Infants with initial...
Preparation and in vitro Physical Activities of Crude Natural Surfactant and Artificial Pulmonary Surfactant Containing Synthetic Peptide and Phospholipid Mixtures
Joo Hyun Kang, Song Yub Shin, Cheol-Young Maeng, Kil Lyong Kim, Chong-Woo Bae, Kyung-Soo Hahm
Clin Exp Pediatr. 1998;41(4):472-480.   Published online April 15, 1998
Purpose : In this study, natural pulmonary surfactant was extracted from bovine lung lavage and its surface activity was determined. To investigate the usefulness of synthetic peptides reconstituted with phospholipid as artificial surfactant, truncated peptides from surfactant protein (SP)-B were synthesized and restored the surface tension lowering activities when appropriately recombined with phospholipid. Methods : Crude natural surfactant(CNS) was isolated from lung lavage by centrifugation...
Case Report
Protein Losing Entropathy Due to TB Enterocolitis was Detected by 99mTc-Human Serum Albumin Scan
Hyoung No Kim, Jae Won Huh, Sang Gun Bee, Yong Woon Back, Chang Hyun Lee
Clin Exp Pediatr. 1997;40(12):1750-1755.   Published online December 15, 1997
Protein losing entropathy was a secondary disorder of the gastrointestinal tract, which is associated with lymphatic obstruction, inflammatory and noninflammatroy disease. It' s clinical manifestations were abdominal pain, edema, diarrhea and growth failure. We described a 12-year-old boy, who had chronic diarrhea for 3 months and edema of lower extremities for 7 days. He also had severe hypoalbuminemia, iron definency anemia, liver diseases and malnurition,...
A Case of Intestinal Amebiasis with Protein Losing Enteropathy
Chan Young Pak, Hee Taeg Kim, Soo Young Choi, Yun Jong Kang, Yeon Chung Chung, Jin Keun Ghang, Jeong Kee Seo
Clin Exp Pediatr. 1997;40(10):1458-1464.   Published online October 15, 1997
Amebiasis is an infectious disease caused by Entameba histolytica. Amebiasis remains an extremely important consideration in the differential diagnosis of diarrhea, especially when there is associated bleeding. It is imperative that appropriate studies to establish or exclude the diagnosis of amebiasis be carried out in all patients who present with a clinical and sigmoidoscopic picture of colitis, and that patients treated with metronidazole for amebiasis...
Original Article
Complications, Apolipoproteins and Lipoprotein(a) in Severely Obese Children in Incheon, 1996
Yon Ho Choe, Yong Hoon Jun, Soon Ki Kim, Seung Kyu Han, Byong Kwan Son, Jong Weon Choi, Soo Hwan Pai
Clin Exp Pediatr. 1997;40(10):1386-1393.   Published online October 15, 1997
Purpose : This study was designed to evaluate the incidence of complication in severely obese children and to determine whether the difference of Lp(a) between severely obese children and normal control group exists. Methods : Body weight, height and obesity index were measured in 5885(M:F= 3089:2796) elementary school children. Eight eight(M:F=63:25) were selected as severely obese children. Of the 88 children, 74 agreed to venous...
Analysis of Urinary Mass Screening for Elemantary, Junior and High School Children Over a 8-year Period in Seoul
Chong Guk Lee, Dong Whan Lee, Sae Won Yang, Sung Ho Cha, Chang Ho Hong, Yong Mook Choi, Hyun Soon Lee, Sung Jae Seo
Clin Exp Pediatr. 1997;40(10):1347-1359.   Published online October 15, 1997
Purpose : The urinary mass screening program for the detection of proteinuria had been performed for a school age population in the city of Seoul since 1981. However, systematic evaluation for this program had never been done. We, therefore, designed a systematic evaluation in corporation with the Seoul School Health Center for students with proteinuria identified in the mass screening to determine the prevalence...
Immunohistochemical Study of Bcl-2 Oncoprotein Expression in Childhood Non-Hodgkin's Lymphoma
Sung Mee Kim, Jin Hwa Jung, Jeong Ho Lee, Jong Dae Jo, Young Tak Lim, Do Youn Park, Sun Kyeung Lee
Clin Exp Pediatr. 1997;40(9):1265-1274.   Published online September 15, 1997
Purpose : The aim of the present study was to assess the clinicopatholgical significance of Bcl-2 oncoprotein expression in childhood non-Hodgkin' s lymphoma(NHL). Methods : We have assessed 16 cases of childhood NHL during last 6 years from 1990 to 1995. Bcl-2 oncoprotein expression has been semiquantitatively analyzed in paraffin sections from 16 cases of childhood NHL with 39 control cases of adult NHL. The...
Zinc and Copper Concentrations and Their Correlation with Protien in Cerebrospinal Fluid of Children with Neurologic Disorders
Myung Joon Cha, Young Joon Kim, Ha Joo Choi, Woo Kap Chung
Clin Exp Pediatr. 1997;40(8):1062-1070.   Published online August 15, 1997
Purpose : The importance of trace elements in their effect on the physiology and pathology of the central nervous system is well recognized. Changes in the concentrations of these elements in the brain could take place in pathological states. Recently, a greater emphasis has been given to the role of trace elements in the function of the nervous system both in normal and pathological...
Lipid Profile and Its Association with Coronary Aneurysm in Kawasaki Disease
Ju Sik Choi, Suk Min Choi, Kyu Hyung Lee
Clin Exp Pediatr. 1997;40(6):835-840.   Published online June 15, 1997
Purpose : The value of serum lipid in children after recovery of Kawasaki disease may be important because of the predilection of this disease for the coronary artery. Methods : We measured serum high density lipoprotein(HDL)-cholesterol, total cholesterol, triglycerides in 22 patients (mean age 38months, range 6 to 93 months) with Kawasaki disease during 10 days or less after onset and 2 months later...
Plasma Fibronectin Concentration in the Premature,Fullterm Neonates and Infants
Hyun Joo Lee, Kyung Hyo Kim, Gyoung Hee Kim
Clin Exp Pediatr. 1997;40(4):473-479.   Published online April 15, 1997
Purpose : Plasma fibronectin has important role in the inflammatory response as non-specific opsonin and host defense. Plasma fibronectin concentration is different according to age and presence of infection. We performed this study to evalulate plasma fibronectin concentration in the healthy preterm, term neonates and infants and how that correlate with gestational age and birth weight and increased CRP concentration....
Case Report
Erythrocyte Band 7 Integral Protein Defectin Congenital Hemolytic Anemia: Hereditary Stomatocytosis
Chang Seoup Sim, Sang Joo Han, Hong Jin Lee, Woo Ill Park, Kyung Ja Lee, So Young Chung, Sechan Woo, Eui Yul Choi
Clin Exp Pediatr. 1997;40(2):260-264.   Published online February 15, 1997
Hereditary stomatocytosis is a rare congenital hemolytic anemia, named after mouth shaped or stomatocytic erythrocyte morphology. In this report, we present a case of a hereditary stomatocytosis in a 1 month old boy. During the initial identification process, we overlooked the morphology of the RBC in peripheral blood smear and tentatively diagnosed it to be a hereditary spherocytosis case. In order to...
Original Article
Serum EosinophilCationic Protein Levelsin Patients with Recurrent Croup
Moon Kil Bahng, Do Yoon Lee, Mee Kyung Namgoong, Jong Soo Kim
Clin Exp Pediatr. 1997;40(2):194-198.   Published online February 15, 1997
Purpose : Most patients suffer from croup only once in a life time. However, a small group of patients suffer from it several times. A type of croup from which they suffer more than 3 times is called recurrent croup. The cause of recurrent croup has not been clearly described, but in recent years the allergic reaction is considered as a...
The Characteristics of Insulin-like Growth Factor Binding Protein-3(IGFBP-3) in Serum; The Diagnostic Utility of IGFBP-3 in Growth Hormone Deficiency
Ki-Joong Kim, Jeh-Hoon Shin, Young-Ik Lee
Clin Exp Pediatr. 1996;39(11):1594-1599.   Published online November 15, 1996
Purpose : For diagnosis of growth hormone(GH) deficiency in short stature, peak growth hormone levels after pharmacologic stimulation are usually used. In this study, we measured serum IGFBP-3, which is a major binding protein in serum and is considered to be GH-IGF-I axis dependent, levels by radioimmuno assay(RIA) in sera from normal short stature(NSS) children, and patients with GH deficiency children to clarify the...
Diagnosis and Treatment of Fetal Cardiac Anomalies
Nam Su Kim, Myung Kul Yum, Hahng Lee, Sung Ro Jung, Jung Bae Yoo, Jae Ek Lee
Clin Exp Pediatr. 1996;39(10):1395-1404.   Published online October 15, 1996
Purpose : Fetal echocardiography is used for the prenatal diagnosis of congenital heart disease. Fetal echocardiography allows decisions to be made in advance where the fetal abnormality is not compatible with life after delivery or where early correction is required. Our fetal echocardiographic experience was analysed retrospectively to guide future clinical application. Methods : 138 mothers had fetal echocardiography from April 1992 to December...
Surfactant Protein SP-A, B, and C: Purification and Biochemical Characterization
Chong-Woo Bae, Yong-Mook Choi, Joo Hyun Kang, Kil Lyong Kim, Kyung Soo Hahn
Clin Exp Pediatr. 1996;39(2):218-229.   Published online February 15, 1996
Purpose : Several kinds of exogenous pulmonary surfactants (SF), either synthetic or animalderived, are being used for the replacement therapy in respiratory distress syndrome (RDS) of newborn, especially in premature infants, and improved the neonatal mortality and morbidity. Because synthetic preparations are lack of surfactant protein (SP) and animal-derived preparations cause immunogenecity of heterogenous SP, there have been great necessity for the development of next...
Case Report
A Case of the Renal Artery Aneurysm Associated with the Dysplastic Kidney
Tae Hee Park, Soo Hee Chang, Young Min Han, Soo Chul Cho, Dae Yeol Lee
Clin Exp Pediatr. 1995;38(11):1571-1576.   Published online November 15, 1995
Multicystic dysplastic kidney is the most frequent cause of abdominal mass in the neonate. It is frequently associated with contralateral genitourinary tract abnormalities and the most common abnormality is vesicoureteral reflux. Renal artery aneurysm is very rare in the children. Furthermore the case associated with the renal artery aneurysm has not been reported yet. We experienced a case of the left...
Original Article
A Follow-Up Study of Intractable Diarrhea in Early Infancy: Clinical Features of Cow's Milk Allergy and Cow Milk-Sensitive Enteropathy
Young Rak Kwon, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(11):1515-1524.   Published online November 15, 1995
Purpose : The multiplicity of poorly defined illnesses and the variability of clinical and laboratory features elicited by milk ingestion in sensitized infants has made it difficult to differentiate them from the more common forms of cow milk intolerance. Following up the cases of intractable diarrhea in early infancy(illI), We investigated the clinical features of cow's milk allergy(CMA) and cow...
Serum 2-microglobulin and Retinol Binding Protein and Urine 2-microglobulin and 1-microglobulin in Early Neonatal Period
Jong Duck Kim, Jae Kak Choi, Yong Hwoe Moon
Clin Exp Pediatr. 1995;38(9):1176-1184.   Published online September 15, 1995
Purpose : For evaluation of usefulness of the serum .2-microglobulin(B2MG), retinol binding protein(RBP), urine 1-microglobulin(A1MG), and B2MG on neonatal renal function and renal tubular injuries, we detected and compared these values in 20 neonates. Methods : They were grouped into premature neonate, gestational age was 30-50 weeks(group Ⅰ), and full term neonate, gestational age was 38-40 weeks(group Ⅱ), The group Ⅱ...
Intractable Diarrhea in Early Infancy : Clinical Features on Admission and A Nutritional Management
Jong Won Shin, Kyung Won Hwang, Young Ho Ahn, Jin Bok Hwang, Chang Ho Han, Hai Lee Chung, Young Dae Kwon
Clin Exp Pediatr. 1995;38(7):936-945.   Published online July 15, 1995
Purpose : We studied to assess the value of clinical findings on admission in screening of intractable diarrhea in early infancy(IDI) and the efficiency of early trial of semi-elemental form-ula (protein hydrolysate) as a nutritional management in IDI. Methods : We carried out a retrospective review of medical records of twenty-eight early infants with diarrhea and malnutrition who were diagnosed as...
Plasma Lipid Alteration in Leukemia and Solid Tumor
Eun Sik Kang, Myoung Soon Song, Hea Jin Cheoh, Kyu Chul Choeh
Clin Exp Pediatr. 1995;38(4):529-536.   Published online April 15, 1995
Purpose : A sensitive, specific blood test to detect cancer would be of great value but the search for such a test has been fruitless so far. In actual practice, there is often a considerable interval between the point at which a tumor could have been detected and the point at which it produces symptoms as a result of tumor...
Case Report
A Case of Type V Hyperlipoproteinemia
Yo Ahn Rho, Jong Kwang Lee, Kee Hwan Yoo, Joo Won Lee, Soon Kyum Kim
Clin Exp Pediatr. 1994;37(12):1752-1756.   Published online December 15, 1994
The hyperlipoproteinemias are the disturbance of lipid transport resulted from accelerated synthesis or retarded degradation of lipoproteins that transport cholesterol and trigycerides through plasma. These diseases are classified as type I, type IIa, type IIb, type III, type IV, type V, and hyper-α-triglyceride levels due to increases in both VLDL and chylomicrons and lipoprotein electrophoresis shows increases pre-β, β, and...
Original Article
Characteristics of Insulin-Like Growth Factor I in Serum; Pattern of Insulin-Like Growth Factor Binding Protein (Large Complex) in Short Stature Patients with Complete Growth Hormone Deficiency
Jin Nyoung Park, Byung Deok Seo, Jeh Hoon Shin, Soo Ji Moon, Sung Yeoul Chang
Clin Exp Pediatr. 1994;37(11):1548-1559.   Published online November 15, 1994
To elucidate the complex of insulin-like growth factor binding proteins (IGF-BPs) in short stature patients, we carried out a prospective study on three patients who were diagnosed as complete GH deficiency at the department of pediatrics form July 1992 to June 1993. The results were summarized as follows: 1) Two circulating IGFs complexed to specific binding protein existed in normal serum. Binding...
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